MOTS-c
1. General Research Description
MOTS-c (Mitochondrial ORF of the Twelve S-c) is a short peptide encoded within the mitochondrial 12S rRNA region and is classified as a mitochondrial-derived peptide (MDP). Structurally, MOTS-c consists of a 16-amino-acid sequence that is noted in scientific literature for its unique mitochondrial origin and its ability to interact with nuclear and cytosolic pathways under controlled laboratory conditions. This compact peptide structure makes MOTS-c valuable for examining intracellular signaling behavior, metabolic stress responses, and peptide–protein interaction models.
In research environments, MOTS-c is frequently studied for its role in cellular stress adaptation, energy-related biochemical pathways, and investigations involving mitochondrial–nuclear communication. Published laboratory studies highlight its relevance in experiments assessing AMPK-associated signaling cascades, metabolic regulation models, and peptide-induced gene expression responses. Due to its defined structure and predictable in-vitro behavior, MOTS-c is often used in controlled experiments exploring peptide stability, receptor binding tendencies, and intracellular transport mechanisms.
MOTS-c is also referenced in research focusing on mitochondrial peptides as regulators of cellular homeostasis, making it useful for studying biochemical communication between mitochondrial DNA–encoded elements and broader metabolic networks. Its naturally occurring presence in mitochondrial genomes allows researchers to examine cross-compartment signaling pathways, structural peptide analog development, and metabolic flux modeling.
2. Storage & Handling
• Store lyophilized MOTS-c at –20°C or below
• Keep vials sealed and protected from moisture, heat, and light exposure
• After reconstitution, store the solution at 2–8°C
• Avoid repeated freeze–thaw cycles to maintain peptide integrity
• Use sterile laboratory technique and appropriate protective equipment
• Intended solely for controlled, non-clinical scientific research applications
3. FAQ
Q: What type of research is MOTS-c commonly used for?
A: MOTS-c is commonly used in research studying cellular energy regulation pathways, mitochondrial-derived peptide signaling, metabolic stress response models, and intracellular communication mechanisms.
Q: How should MOTS-c be stored after reconstitution?
A: After reconstitution, MOTS-c should be stored at 2–8°C. For extended research use, aliquoting and freezing at –20°C is recommended to preserve peptide stability.
Q: What format does MOTS-c come in?
A: MOTS-c is supplied as a lyophilized peptide powder in sealed, research-grade vials to maintain stability during storage and laboratory handling.
4. Legal Disclaimer
Not for human consumption
Not for veterinary use
Not for medical or diagnostic use
For laboratory and scientific study only
No claims of safety, efficacy, or intended therapeutic use
Buyer assumes all responsibility for proper handling, storage, and use