How Peptides Are Synthesized: An Overview of Solid-Phase Peptide Synthesis

Solid-phase peptide synthesis (SPPS) is the most widely used method for producing research-grade peptides. By anchoring the initial amino acid to a resin bead, researchers can build sequences step-by-step using automated or manual chemistry cycles.

The process offers high precision, scalability, and flexibility for designing modified or custom peptide structures. After synthesis, purification and analytical verification ensure the compound meets quality specifications.

SPPS revolutionized modern peptide research, enabling consistent and rapid production of complex sequences.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416801/
https://pubmed.ncbi.nlm.nih.gov/30787263/
https://www.sciencedirect.com/topics/chemistry/solid-phase-peptide-synthesis